5-MeO-DMT is routinely used to alleviate depression, anxiety, PTSD, and addiction. It’s sometimes used alongside ibogaine treatment to help patients integrate what they’ve learned. Limited clinical research appears to support such use of 5-MeO-DMT in treating addiction and depressive disorders.In a recent European study, after one single use, the substance 5-MeO-DMT was shown to produce sustained enhancement of satisfaction with life, and easing of anxiety, depression and post-traumatic stress disorder